The effects of Daebangpoongtang on the liver, stomach, kidney and spleen of normal and collagen-induced arthritis rats were investigated using histological and histochemical methods.
The results were as follows ;
1. The slight cloudy swelling was observed in the liver of Daebangpoongtang treated normal rats (N-DA) as compared with normal rats, however additional changes such as inflammation and denser PAS stainability in cytoplasm showed in both D.W treated arthritis rats (A-DW) and Daebangpoongtang treated arthritis rats (A-DA).
2. In the stomach, a few disordered surface epithelial lining were seen and difference stainabilities of PAS and sWGA were also demonstrated.
3. In the kidney, a few injuried cells occured in the proximal convoluted tubule of N-DA. And with these changes, unclear glomerulus and Bowman’s capsule as well as different stainabilities of PAS, SBA aid BSL-1 were present in the A-DW and A-DA.
4. No siginficant difference existed between normal and experimental group in the spleen.
The morphological and histochemical changes of internal organs in the A-DW and A-DA were noted slight inflammation and different stainabilities as compared with normal rats, while these changes were not significant in the N-DA. Consequently above results suggest that Daebangpoongtang has temporary effect on the normal rats.
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